Entrepreneurship is a key driver of economic growth and social mobility, but systemic inequalities have historically impeded the progress of marginalized communities, specifically African Americans and Native Americans. Despite their significant contributions to America’s culture, economics, and overall development these groups of people continue to still face obstacles and challenges that inhibit them from achieving in their entrepreneurial pursuits. Historical evaluations often minimize or overlook the problems experienced by African Americans and Native Americans, by blaming the cultures of these groups for their low self-employment rates. Recent research underscores the intersectionality of race, ethnicity, and socioeconomic status in determining entrepreneurial behavior. This thesis explores the variables that influence self-employment rates among African American and Native American men in the United Stated using a quantitative analysis of IPUMS ACS data covering the years 2000-2022.